Heart Failure Clinical Trial

Introduction: Setting the Stage for Innovative Heart Failure Research

Ormond Beach Clinical Research is at the forefront of transformative clinical trials aimed at improving patient outcomes. One of our most recent contributions to medical research is a groundbreaking clinical trial focused on Heart Failure. This comprehensive study delves into the effectiveness of single and multiple ascending doses (SAD and MAD) of a new investigational drug known as AZD3427.

Overview of the Heart Failure Clinical Trial Design

Our clinical trial was a multi-center study planned with a total of 104 participants. The trial was divided into two distinct parts: Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD), known as Part A and Part B respectively.

Part A (SAD): A Closer Look

  • Number of Cohorts: 7
  • Participants: 8 healthy volunteers in each cohort
  • Randomization: AZD3427 or placebo, randomized in a 6:2 ratio
  • Special Cohort: One cohort specifically included participants of Japanese descent

Part B (MAD): Unlocking the Mystery of Heart Failure

  • Number of Cohorts: 6
  • Participants: 8 patients in each cohort
  • Randomization: AZD3427 or placebo, randomized in a 6:2 ratio
  • Specialized Cohorts: 3 cohorts with Heart Failure with Reduced Ejection Fraction (HFrEF) and 3 cohorts with Heart Failure with Preserved Ejection Fraction (HFpEF)

The Timeline: What Participants Can Expect

  • Maximum Screening Period: 27 days
  • Day 1: Study drug administration for participants in both Part A and Part B
  • Additional Doses for Part B: Days 8, 15, 22, and 29
  • Follow-Up: Participants will be monitored for at least 50 days after the last dose of the study drug

Why This Heart Failure Trial Matters

This condition is a global public health concern, affecting millions worldwide. Our study aims to pave the way for new treatment modalities, specifically focusing on the varying nature of heart failure as demonstrated by the inclusion of HFrEF and HFpEF cohorts.

Conclusion: A Step Forward in Research

This clinical trial conducted by Ormond Beach Clinical Research showcases our commitment to advancing medical research. We are eagerly awaiting the results and are hopeful that they will provide invaluable insights into the management and treatment of.

For those interested in participating in future trials or learning more about our ongoing research, please get in touch with us. Together, we can make a meaningful impact on the world of research.